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Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses

机译：CD3和CD28的肿瘤局部结扎与系统性调节性T细胞耗竭诱导有效的先天性和自适应抗肿瘤反应

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Bing-mae Cheng; Steve R. Roffler;
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年度 2014
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1. Tumor-localized ligation of CD3 and CD28 with systemic regulatory T-cell depletion induces potent innate and adaptive antitumor responses. [J] . Lee CH, Chiang YH, Chang SE, Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第8期

机译：CD3和CD28与全身调节性T细胞耗竭的肿瘤局部结扎可诱导有效的先天性和适应性抗肿瘤反应。
2. Induced regulatory T-cells (iTregs) generated by activation with anti-CD3/CD28 antibodies differ from those generated by the physiological-like activation with antigen/APC [J] . Zhao Chan, Shi Guangpu, Vistica Barbara P., Cellular immunology . 2014,第2期

机译：通过抗CD3 / CD28抗体激活产生的诱导调节性T细胞（iTreg）与通过抗原/ APC进行生理样激活产生的诱导性T细胞不同
3. CD4 T-cells transduced with CD80 and 4-1BBL mRNA induce long-term CD8 T-cell responses resulting in potent antitumor effects [J] . Park Hye-Mi, Sohn Hyun-Jung, Kim Yoo-Jin, Vaccine . 2014,第51期

机译：CD80和4-1BBL mRNA转导的CD4 T细胞诱导长期CD8 T细胞反应，从而产生有效的抗肿瘤作用
4. Potent Antitumor Activity of IL-2-Fc Fusion Proteins Through FcyR-Dependent Depletion of Regulatory T-Cells [C] . Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, International Molecular Medicine Tri-Conference. . 2016

机译：通过依赖于调节T细胞的Fcγ1-2-Fc融合蛋白的有效抗肿瘤活性
5. Innate and adaptive immune mechanisms that induce pathogenic Th17 responses in murine schistosomiasis. [D] . Shainheit, Mara G. 2010

机译：在小鼠血吸虫病中诱导致病性Th17反应的先天性和适应性免疫机制。
6. PNAS Plus: Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity [O] . Masanori Onda, Kazuto Kobayashi, Ira Pastan 2019

机译：PNAS Plus：用抗CD25免疫毒素清除肿瘤中的调节性T细胞可诱导CD8 T细胞介导的全身性抗肿瘤免疫力
7. Combination of Tumor Site–Located CTL-Associated Antigen-4 Blockade and Systemic Regulatory T-Cell Depletion Induces Tumor-Destructive Immune Responses [O] . Sebastian Tuve, Bing-Mae Chen, Ying Liu, 2007

机译：肿瘤位点的组合CTL相关抗原-4封闭和全身调节T细胞耗尽诱导肿瘤破坏性免疫反应

Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses

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